Unlike selective serotonin reuptake inhibitors or SSRIs that mainly works on a specific chemical on the brain called serotonin, atypical antidepressants on other hand, particularly the newer varieties, work on other neurotransmitters either alone or in addition to serotonin.
They also work on some other chemicals like norepinephrine and dopamine that actually both play significant roles in the development of depression.
Examples of Atypical Antidepressants
Atypical antidepressants normally includes:
- Bupropion (Wellbutrin)
- Venlafaxine (Effexor)
- Duloxetine (Cymbalta)
- Mirtazapine (Remeron)
- Trazodone (Desyrel)
- Nefazodone (Serzone)
Among all the atypical antidepressants above, buproprion or most well-known as Wellbutrin on the market, is actually the best-selling one. Venlafaxine or Effexor is also doing great on the market but buproprion or wellbutrin is doing much better because it is popular for not causing much problems associated with sexual dysfunction.
Usually, SSRIs cause problems relating to sexual drive or dysfunction and somehow to avoid untoward events, buproprion or wellbutrin is used as a support medication or addition, however, this is actually a case-to-case basis, all depending in your situation or condition.
Common Adverse Effects of Atypical Antidepressants
The adverse effects the user may experience actually vary, depending on the particular atypical antidepressant drug used or taken. However, there are some adverse effects found common in most atypical antidepressant varieties. These common adverse effects may actually include:
- Nausea
- Fatigue
- Weight gain
- Sleepiness
- Nervousness
- Dry mouth
- Blurred or slurred vision


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